Disopyramide

Disopyramide is a sodium channel blocker that, in rabbit ventricular myocytes, binds and dissociates from open channels more quickly than from resting channels. It is a class Ia antiarrhythmic agent that delays conduction through the AV node and ventricles of the dog heart both in vivo (3 and 5 mg/kg) and in vitro (1-2 mg/L). Formulations containing disopyramide have been used in the treatment of cardiac arrhythmias and hypertrophic cardiomyopathy.Formal Name: alpha-[2-[bis(1-methylethyl)amino]ethyl]-alpha-phenyl-2-pyridineacetamide. CAS Number: 3737-09-5. Synonyms: (±)-Disopyramide, Ritmilen, SC-7031. Molecular Formula: C21H29N3O. Formula Weight: 339.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Chloroform: slightly soluble, Ethanol: >1 mg/ml, Methanol: slightly soluble. lambdamax: 262 nm. SMILES: O=C(N)C(C1=CC=CC=C1)(CCN(C(C)C)C(C)C)C2=CC=CC=N2. InChi Code: InChI=1S/C21H29N3O/c1-16(2)24(17(3)4)15-13-21(20(22)25,18-10-6-5-7-11-18)19-12-8-9-14-23-19/h5-12,14,16-17H,13,15H2,1-4H3,(H2,22,25). InChi Key: UVTNFZQICZKOEM-UHFFFAOYSA-N.