Dipivefrin (hydrochloride)

Dipivefrin is a prodrug of epinephrine that is hydrolyzed by cholinesterase and other esterases in the cornea to epinephrine. It reduces the density of cultured bovine primary trabecular meshwork cells (IC50 = 115 µM). Additionally, it induces an elongated, fibroblast-like morphology and disrupts the actin cytoskeleton in bovine primary trabecular meshwork cells when used at a concentration of 103 µM. In cultured bovine corneal endothelial cells, dipivefrin (28 µM) enhances calcium signaling and induces cytotoxicity. Dipivefrin also suppresses primary human corneal keratinocyte proliferation when used at a concentration of 280 µM. Formulations containing dipivefrin have been used alone and in combination with beta-adrenergic receptor antagonists for the treatment of glaucoma.Formal Name: 2,2-dimethyl-propanoic acid, 1,1'-[4-[1-hydroxy-2-(methylamino)ethyl]-1,2-phenylene] ester, monohydrochloride. CAS Number: 64019-93-8. Molecular Formula: C19H29NO5 . HCl. Formula Weight: 387.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 33 mg/ml, DMSO: 33 mg/ml, Ethanol: 33 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: O=C(C(C)(C)C)OC1=C(OC(C(C)(C)C)=O)C=C(C(CNC)O)C=C1.Cl. InChi Code: InChI=1S/C19H29NO5.ClH/c1-18(2,3)16(22)24-14-9-8-12(13(21)11-20-7)10-15(14)25-17(23)19(4,5)6,/h8-10,13,20-21H,11H2,1-7H3,1H. InChi Key: VKFAUCPBMAGVRG-UHFFFAOYSA-N.