Diphenidol (hydrochloride)

Diphenidol is an antagonist of muscarinic acetylcholine receptors (mAChRs, Kis = 0.43, 2.8, 1.1, 0.91, and 1.28 µM in CHO cell membranes expressing M1-5 receptors, respectively). It also inhibits Kv channels in Neuro2A cells (IC50 = 28.2 µM), as well as L-type voltage-gated calcium channels in differentiated NG 108-15 cells in a concentration-dependent manner. Microiontophoretic application of diphenidol inhibits rotation-induced firing of medial vestibular nucleus neurons in a cat model of vertigo. Diphenidol (3.2 mg/kg, i.v.) prevents apomorphine-induced emesis in dogs. Formulations containing diphenidol have been used in the treatment of vertigo and as antiemetics.Formal Name: alpha,alpha-diphenyl-1-piperidinebutanol, monohydrochloride. CAS Number: 3254-89-5. Synonyms: SKF 478A. Molecular Formula: C21H27NO . HCl. Formula Weight: 345.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 2 mg/ml. SMILES: OC(C1=CC=CC=C1)(CCCN2CCCCC2)C3=CC=CC=C3.Cl. InChi Code: InChI=1S/C21H27NO.ClH/c23-21(19-11-4-1-5-12-19,20-13-6-2-7-14-20)15-10-18-22-16-8-3-9-17-22,/h1-2,4-7,11-14,23H,3,8-10,15-18H2,1H. InChi Key: AVZIYZHXZAYGJS-UHFFFAOYSA-N.