Dicoumarol

Dicoumarol is a competitive inhibitor of NADH:quinone oxidoreductase (NQO1) with IC50 values of 2.6 and 404 nM in the absence and presence of 2 µM BSA, respectively. It has antiproliferative activity against MIA PaCa-2 pancreas and HCT116 colon carcinoma cells (IC50s = 52 and 19 µM, respectively, after a 96 hour incubation). Dicoumarol inhibits stress-activated protein kinase (SAPK) in HEK293 cells (IC50 = 19-33 µM) at a point upstream of MEKK1 and downstream of TNF receptor-associated factor 2 (TRAF2), and it inhibits TNF-alpha and LPS-induced NF-kappaB activation in HeLa cells. It also has antiproliferative activity against FL5.12 lymphocytic and MCF-7 breast carcinoma cells (100 µM) by suppressing JNK activation.Formal Name: 3,3'-methylenebis[4-hydroxy-2H-1-benzopyran-2-one. CAS Number: 66-76-2. Synonyms: NSC 17860, NSC 41834, NSC 221570. Molecular Formula: C19H12O6. Formula Weight: 336.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1.25 mg/ml, DMSO: 2.5 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: slight solubility. lambdamax: 309 nm. SMILES: O=C1C(CC2=C(O)C(C=CC=C3)=C3OC2=O)=C(O)C4=CC=CC=C4O1. InChi Code: InChI=1S/C19H12O6/c20-16-10-5-1-3-7-14(10)24-18(22)12(16)9-13-17(21)11-6-2-4-8-15(11)25-19(13)23/h1-8,20-21H,9H2. InChi Key: DOBMPNYZJYQDGZ-UHFFFAOYSA-N.