48 products were found matching "K05357"!

Dicoumarol is a competitive inhibitor of NADH:quinone oxidoreductase (NQO1) with IC50 values of 2.6 and 404 nM in the absence and presence of 2 µM BSA, respectively. It has antiproliferative activity against MIA PaCa-2 pancreas and HCT116 colon carcinoma cells (IC50s = 52 and 19 µM, respectively, after a 96 hour...

(±)-Warfarin (Cay-13566) is a vitamin K antagonist, a coumarin derivative, and a racemic mixture of (+)-warfarin (Cay-13526) and (-)-warfarin (Cay-13531). It is an anticoagulant that interferes with interconversion of vitamin K and vitamin K epoxide and the role of vitamin K in carboxylation of several clotting...

Description: Warfarin-d5 is a deuterated compound of Warfarin. Smiles: C(CC(C)=O)(C1=C(O)C=2C(OC1=O)=CC=CC2)C3=C(C(=C(C(=C3[2H])[2H])[2H])[2H])[2H]

(-)-Warfarin is a component of (±)-warfarin (Cay-13566). It is an anticoagulant that interferes with interconversion of vitamin K and vitamin K epoxide and the role of vitamin K in carboxylation of several clotting cascade proteins, inhibiting the initiation of clotting. In vivo, (-)-warfarin slows formation of the...

Acenocoumarol is a short-lived oral anti-coagulant, which, like warfarin, functions by inhibiting vitamin K epoxide reductase. It has higher intrinsic anticoagulant potency than warfarin and phenprocoumon, when evaluated in vitro. Acenocoumarol has a single chiral center that gives rise to two different enantiomeric...

Vitamin K is a dietary nutrient essential for the normal biosynthesis of factors that are required for blood clotting. It has also been shown to inhibit cell growth. Vitamin K1 2,3-epoxide is the inactive metabolite of vitamin K1. During clotting, vitamin K1 is converted to this epoxide form and then rapidly reduced...

Phenprocoumon is an anticoagulant and vitamin K antagonist. It inhibits the activity of wild-type vitamin K epoxide reductase (VKOR, IC50 = 4.2 nM), as well as a variety of mutant VKORs (IC50s = 5.1-835 nM), in cell-based reporter assays. Phenprocoumon inhibits prothrombin complex synthesis in rats in a...

Optically active R enantiomer of Warfarin. S-warfarin is found to be more potent than the R-isomer in producing an anticoagulant response.

Optically active S enantiomer of Warfarin Sodium. Used for preventing thrombosis and embolism. A synthetic derivative of coumarin. Decreases blood coagulation by inhibiting vitamin K epoxide reductase.

Optically active R enantiomer of Warfarin Sodium. Used for preventing thrombosis and embolism. A synthetic derivative of coumarin. Decreases blood coagulation by inhibiting vitamin K epoxide reductase.

Acenocoumarol is an anticoagulant and vitamin K antagonist. It inhibits the reduction of vitamin K1 epoxide to vitamin K1 by vitamin K1 epoxide reductase (VKOR) (IC50 = 1.5 and 5.8 nM for VKORC1 and VKORC1L1, respectively). Acenocoumarol also inhibits a variety of VKOR mutants in cell-based reporter assays (IC50s =...