Diclofenac (epolamine)

Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 0.9-2.7 and 1.5-20 µM, for human COX-1 and COX-2, respectively). It is also an active metabolite of diclofenac methyl ester (Cay-22218) and diclofenac amide (Cay-21969). Diclofenac inhibits release of arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) induced by A23187 (Cay-11016) in isolated rat peritoneal neutrophils and macrophages (IC50s = 60 and 10 µM, respectively). Transdermal administration of diclofenac inhibits carrageenan-induced paw edema in rats. Formulations containing diclofenac have been used in the treatment of pain associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. InChI: InChI=1S/C14H11Cl2NO2.C6H13NO/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19,8-6-5-7-3-1-2-4-7/h1-7,17H,8H2,(H,18,19),8H,1-6H2 InChIKey: DCERVXIINVUMKU-UHFFFAOYSA-N SMILES: O=C(CC1=C(NC2=C(Cl)C=CC=C2Cl)C=CC=C1)O.OCCN3CCCC3