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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay14576-100 | 100 mg | - |
6 - 10 business days* |
87.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Diazoxide is an activator of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium... more
Product information "Diazoxide"
Diazoxide is an activator of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (EC50 = 14.1 µM in a FLIPR assay using HEK293 cells). It also activates SUR2A/Kir6.2 and SUR2B/Kir6.2 channels in HEK293T cells in a patch-clamp assay when used at concentrations of 30 and 300 µM. Diazoxide inhibits glucose-induced insulin release from isolated rat pancreatic beta cells and induces relaxation of isolated rat aortic rings precontracted with potassium chloride (IC50s = 22.6 and 22.4 µM, respectively). It reduces mean arterial pressure and cerebral blood flow in spontaneously hypertensive rats when administered intravenously as a 5 mg/kg bolus dose. Diazoxide (50 mg/kg, i.p.) increases blood glucose levels in mice. Formulations containing diazoxide have been used in the treatment of hypoglycemia.Formal Name: 7-chloro-3-methyl-1,1-dioxide-2H-1,2,4-benzothiadiazine. CAS Number: 364-98-7. Synonyms: NSC 64198, NSC 76130, SRG 95213. Molecular Formula: C8H7ClN2O2S. Formula Weight: 230.7. Purity: >99%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml. lambdamax: 267 nm. SMILES: ClC1=CC=C2C(S(NC(C)=N2)(=O)=O)=C1. InChi Code: InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11). InChi Key: GDLBFKVLRPITMI-UHFFFAOYSA-N.
Keywords: | NSC 64198, NSC 76130, SRG 95213, 7-chloro-3-methyl-1,1-dioxide-2H-1,2,4-benzothiadiazine |
Supplier: | Cayman Chemical |
Supplier-Nr: | 14576 |
Properties
Application: | Potassium channel activator |
MW: | 230.7 D |
Formula: | C8H7ClN2O2S |
Purity: | >99% |
Format: | Crystalline Solid |
Database Information
CAS : | 364-98-7| Matching products |
KEGG ID : | K05032 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
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H Phrases: | H302, H315, H319, H335 |
P Phrases: | P261, P264, P270, P271, P280, P312, P321, P330, P301+P310, P302+P352, P304+P340, P305+P351+P338, P332+P313, P337+P313, P362+P364, P405, P403+P233, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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