Diaveridine

Diaveridine is a dihydrofolate reductase (DHFR) inhibitor (Ki = 11.5 nM for the P. falciparum enzyme) with antimicrobial activity. It is active against P. vulgaris, S. aureus, and S. pyogenes in vitro (MICs = 4, 1, and 2 µg/ml, respectively). Diaveridine has anticoccidial activity when administered alone or in combination with sulfaquinoxaline.Formal Name: 5-[(3,4-dimethoxyphenyl)methyl]-2,4-pyrimidinediamine. CAS Number: 5355-16-8. Synonyms: NSC 408735. Molecular Formula: C13H16N4O2. Formula Weight: 260.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: Partially soluble. SMILES: NC1=NC=C(CC2=CC=C(OC)C(OC)=C2)C(N)=N1. InChi Code: InChI=1S/C13H16N4O2/c1-18-10-4-3-8(6-11(10)19-2)5-9-7-16-13(15)17-12(9)14/h3-4,6-7H,5H2,1-2H3,(H4,14,15,16,17). InChi Key: LDBTVAXGKYIFHO-UHFFFAOYSA-N.