diABZI STING Agonist-1

An activator of the STING pathway, induces secretion of IFN-beta in human PBMCs (EC50 = 130 nM), increases serum levels of Ifn-beta, Il-6, Tnf, and Cxcl1 in wild-type, but not Sting-/-, mice at 2.5 mg/kg, inhibits the cytopathic effect of HCoV-229E in infected MRC-5 cells (EC50 = 3 nM), decreases the level of SARS-CoV-2 RNA in primary human bronchial airway epithelial cells in an air-liquid interface assay, decreases tumor volume and increases survival in a CT26 murine colorectal cancer model at 3 mg/kg, this compound is expected to exist in one or both tautomeric forms. Formulation: A solid. InChI: InChI=1S/C42H51N13O7/c1-6-54-31(19-25(3)49-54)39(58)47-41-45-29-21-27(37(43)56)23-33(60-5)35(29)52(41)12-8-9-13-53-36-30(46-42(53)48-40(59)32-20-26(4)50-55(32)7-2)22-28(38(44)57)24-34(36)62-16-10-11-51-14-17-61-18-15-51/h8-9,19-24H,6-7,10-18H2,1-5H3,(H2,43,56)(H2,44,57)(H,45,47,58)(H,46,48,59)/b9-8+. InChIKey: JGLMVXWAHNTPRF-CMDGGOBGSA-N. SMILES: NC(C1=CC(OCCCN2CCOCC2)=C3C(N=C(N3C/C=C/CN4C(NC(C5=CC(C)=NN5CC)=O)=NC6=CC(C(N)=O)=CC(OC)=C64)NC(C7=CC(C)=NN7CC)=O)=C1)=O