Dexamethasone

Dexamethasone is a synthetic glucocorticoid that binds the human glucocorticoid receptor with a higher affinity than a natural ligand, cortisol (Kd = 5 nM versus 17 nM, respectively). Through receptor activation, dexamethasone has both transactivating and transrepressing effects on gene expression, producing, in general, anti-inflammatory results.Formal Name: 9-fluoro-11beta,17,21-trihydroxy-16alpha-methyl-pregna-1,4-diene-3,20-dione. CAS Number: 50-02-2. Synonyms: MK-125, NSC 34521. Molecular Formula: C22H29FO5. Formula Weight: 392.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml, Ethanol: 3 mg/ml. SMILES: O=C1C=C[C@]2(C(CC[C@]3([H])[C@@]2([C@H](C[C@]4([C@]3(C[C@H]([C@]4(O)C(CO)=O)C)[H])C)O)F)=C1)C. InChi Code: InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1. InChi Key: UREBDLICKHMUKA-CXSFZGCWSA-N.