Dexamethasone is a synthetic glucocorticoid that binds the human glucocorticoid receptor with a higher affinity than a natural ligand, cortisol (Kd = 5 nM versus 17 nM, respectively). Through receptor activation, dexamethasone has both transactivating and transrepressing effects on gene expression, producing, in...

Dexamethasone Lipodisq Sterile Solution is a ready-to-use nano-formulated aqueous solution. Dexamethasone, developed in 1957 and granted FDA approval in 1958, is a corticosteroid structurally similar to hydrocortisone and prednisolone. Dexamethasone is used to treat conditions including: endocrine, rheumatic,...

A potent glucocorticoid found to inhibit pulmonary carcinogenesis.

White to off-white powder. Soluble in DMSO (30mg/ml), ethanol (20mg/ml) or methanol (20mg/ml). Chemical. CAS: 50-02-2. Formula: C22H29FO5. MW: 392.5. Dexamethasone is a potent anti-inflammatory and immunosuppressive agent useful in a variety of inflammatory and autoimmune conditions. This synthetic glucocorticoid...

An anti-inflammatory glucocorticoid. Inhibits the expression of the inducible but not the constitutive nitric oxide synthase in vascular endothelial cells (IC50=5 nM). Enhances active cation transport in aortic smooth muscle cells by stimulating the Na+-K+ pump. Has anti-inflammatory and anti-rheumatic properties....