Desmethyl Bosentan

Desmethyl bosentan is an active metabolite of the endothelin receptor antagonist bosentan (Cay-11731). Desmethyl bosentan (25 µM) activates the pregnane X receptor (PXR) in CV-1 monkey kidney cells expressing the human receptor in a reporter assay.Formal Name: 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-hydroxyphenoxy)[2,2'-bipyrimidin]-4-yl]-benzenesulfonamide. CAS Number: 253688-61-8. Synonyms: Ro 47-8634. Molecular Formula: C26H27N5O6S. Formula Weight: 537.6. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: soluble, DMSO: soluble, Methanol: soluble. SMILES: O=S(NC1=NC(C2=NC=CC=N2)=NC(OCCO)=C1OC3=C(O)C=CC=C3)(C4=CC=C(C(C)(C)C)C=C4)=O. InChi Code: InChI=1S/C26H27N5O6S/c1-26(2,3)17-9-11-18(12-10-17)38(34,35)31-22-21(37-20-8-5-4-7-19(20)33)25(36-16-15-32)30-24(29-22)23-27-13-6-14-28-23/h4-14,32-33H,15-16H2,1-3H3,(H,29,30,31). InChi Key: STTLKJGYAWXIPP-UHFFFAOYSA-N.