53 products were found matching "K08540"!

An agonist of PXR and active metabolite of mefloquine, increases the levels of CYP3A4 in a reporter assay using HepG2 cells expressing human PXR (EC50 = 24 µM), induces the expression of mRNA encoding MDR1, CYP2B6, and CYP3A4 in LS 174T cells

12-keto Lithocholic acid is a metabolite of the secondary bile acid deoxycholic acid (DCA, Cay-20756, Cay-18231). Fecal levels of 12-keto lithocholic acid are elevated in rats fed a diet supplemented with cholic acid (Cay-20250) or DCA compared with rats fed a control diet or a diet supplemented with cholesterol...

Pregnenolone carbonitrile (PCN) is a catatoxic steroid that acts as an agonist of the rodent pregnane X receptor (PXR) at µM concentrations. It has been shown to mediate induction of hepatic cytochrome P450 3A, organic anion transporting peptide-2, and cholesterol 7alpha-hydroxylase, regulating both xenobiotic and...

Protein function: Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the...

Trabectedin is an alkaloid that has been found in E. turbinata and has anticancer activity. It is a guanine-specific DNA alkylating agent and an antagonist of the pregnane X receptor (PXR, IC50 = ~3 nM in a reporter assay). Trabectedin reduces viability of DU145 and PC3 human prostate cancer stem cells in a...

Protein function: Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the...

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Nuclear receptor subfamily 1, group I, member 2 Protein function: Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that...

Protein function: Nuclear receptor that binds and is activated by a variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, endogenous compounds and drugs. Response to specific...

Schisandrol B is a lignan originally isolated from S. chinensis that has hepatoprotective activity. It increases the expression of pregnane X receptor (PXR) target genes involved in bile acid metabolism, including Cyp3a11, Ugt1a1, Oatp2, and Mrp3 in mouse liver and CYP3A4, UGT1A1, and OATP2 in HEK293T cells. It also...

ELISA Type: CLIA. Sensitivity: 18.75 pg/mL. Range: 31.25--2000 pg/mL. Protein function: Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially...