Desidustat

Desidustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH). It reduces levels of hypoxia-inducible factor-1alpha (HIF-1alpha), a transcription factor regulated by HIF-PH enzymes, in rat liver and kidney. Desidustat increases the expression of the red blood cell- and iron transport-related genes Epo, Fpn1, and Hamp in rat liver in a model of anemia induced by peptidoglycan-polysaccharide (PGPS). It increases plasma levels of erythropoietin in rats by 10.3- to 40-fold when administered at doses of 15 and 30 mg/kg, respectively. Desidustat (15 and 30 mg/kg) also increases plasma levels of erythropoietin and hemoglobin, as well as the number of circulating red blood cells, in nephrectomized rats in a model of chronic kidney disease-induced anemia. It increases hemoglobin levels and the number of circulating red blood cells in a mouse model of anemia induced by the DNA-crosslinking agent cisplatin (Cay-13119).Formal Name: N-[[1-(cyclopropylmethoxy)-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl]carbonyl]-glycine. CAS Number: 1616690-16-4. Molecular Formula: C16H16N2O6. Formula Weight: 332.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3mg/ml, DMSO: 3mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5mg/ml, Ethanol: 1mg/ml. lambdamax: 233, 291, 335. SMILES: O=C1C(C(NCC(O)=O)=O)=C(O)C2=CC=CC=C2N1OCC3CC3. InChi Code: InChI=1S/C16H16N2O6/c19-12(20)7-17-15(22)13-14(21)10-3-1-2-4-11(10)18(16(13)23)24-8-9-5-6-9/h1-4,9,21H,5-8H2,(H,17,22)(H,19,20). InChi Key: IKRKQQLJYBAPQT-UHFFFAOYSA-N.