Deoxyarbutin

Deoxyarbutin is a tyrosinase inhibitor (IC50 = 17.5 µM for mushroom tyrosinase). It reduces melanin content in isolated dark human melanocytes when used at a concentration of 1.56 µM. Topical administration of deoxyarbutin (5%) induces skin lightening in human skin mouse xenograft models. Deoxyarbutin also inhibits proliferation of B16/F10 murine melanoma cells (EC50 = 39.56 µM). It induces apoptosis and halts the cell cycle at the S phase in B16/F10 cells when used at a concentration of 50 µM. Deoxyarbutin (50 mg/kg) reduces tumor growth in a B16/F10 murine melanoma model.Formal Name: 4-[(tetrahydro-2H-pyran-2-yl)oxy]-phenol. CAS Number: 53936-56-4. Molecular Formula: C11H14O3. Formula Weight: 194.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 25 mg/ml, Ethanol:PBS (pH 7.2) (1:20): 0.04 mg/ml. lambdamax: 225, 289 nm. SMILES: OC1=CC=C(OC2OCCCC2)C=C1. InChi Code: InChI=1S/C11H14O3/c12-9-4-6-10(7-5-9)14-11-3-1-2-8-13-11/h4-7,11-12H,1-3,8H2. InChi Key: GFBCWCDNXDKFRH-UHFFFAOYSA-N.