Decynium-22

Decynium-22 is an inhibitor of monoamine transporters and organic cation transporters (OCTs). It inhibits the plasma membrane monoamine, serotonin (5-HT), norepinephrine, and dopamine monoamine transporters (IC50s = 1.1, 7.9, 30, and 12.9 µM, respectively), and OCT2 and OCT3 (IC50s = 10 and 0.2 µM, respectively) in radioligand binding assays. Decynium-22 also inhibits binding of the alpha1-adrenergic receptor antagonist prazosin (Cay-15023) in mouse hippocampal homogenates (IC50 = 60 nM). It decreases the time stress-sensitive Wistar Kyoto, but not stress-resistant Long-Evans, rats spend immobile in the forced swim test, indicating antidepressant-like activity, when administered at doses of 1 and 10 µg/kg.Formal Name: 1-ethyl-2-[(1-ethyl-2(1H)-quinolinylidene)methyl]-quinolinium, monoiodide. CAS Number: 977-96-8. Synonyms: 1,1'-Diethyl-2,2'-Cyanine. Molecular Formula: C23H23N2 . I. Formula Weight: 454.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 1 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml. lambdamax: 226, 491, 524 nm. SMILES: CCN(C1=CC=CC=C1C=C/2)C2=C\C3=[N+](CC)C4=C(C=CC=C4)C=C3.[I-]. InChi Code: InChI=1S/C23H23N2.HI/c1-3-24-20(15-13-18-9-5-7-11-22(18)24)17-21-16-14-19-10-6-8-12-23(19)25(21)4-2,/h5-17H,3-4H2,1-2H3,1H/q+1,/p-1. InChi Key: GMYRVMSXMHEDTL-UHFFFAOYSA-M.