DBeQ

The ATPase p97 is an ubiquitin-selective chaperone known to play a critical role in the degradation of misfolded membrane and secretory proteins and has been linked to various cellular processes that require unfolding and disassembly of protein complexes. DBeQ is a selective, reversible, and ATP-competitive inhibitor of the ATPase p97 (Ki = 3.2 µM, IC50 = 1.5 µM). It does not exhibit activity when tested against a panel of 170 protein kinases at concentrations as high as 15 µM. At 10 µM it blocks endoplasmic reticulum-associated degradation, impairing the autophagy pathway and promoting the activation of caspase-3 and -7 in cancer cells.Formal Name: N2,N4-bis(phenylmethyl)-2,4-quinazolinediamine. CAS Number: 177355-84-9. Synonyms: N,N'-Dibenzylquinazoline-2,4-diamine, JRF 12. Molecular Formula: C22H20N4. Formula Weight: 340.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, DMSO:PBS(pH 7.2) (1:2): 0.33 mg/ml, Ethanol: 1.4 mg/ml. lambdamax: 238, 281, 340 nm. SMILES: C12=CC=CC=C1N=C(NCC3=CC=CC=C3)N=C2NCC4=CC=CC=C4. InChi Code: InChI=1S/C22H20N4/c1-3-9-17(10-4-1)15-23-21-19-13-7-8-14-20(19)25-22(26-21)24-16-18-11-5-2-6-12-18/h1-14H,15-16H2,(H2,23,24,25,26). InChi Key: QAIMUUJJAJBPCL-UHFFFAOYSA-N.