DB2313 (hydrochloride)

DB2313 is an inhibitor of the transcription factor PU.1 (IC50 = 14 nM). Long-term exposure of DB2313 (300 nM) to Kit+/Sca-1+/Lin- hematopoietic stem progenitor cells (KSL-HSPCs) reduces colony formation. DB2313 (700 nM) decreases ovalbumin-induced reprogramming of isolated mouse neutrophils into antigen-presenting cells. It decreases tumor growth, weight, and volume in a U87MG glioblastoma multiforme mouse xenograft model when administered at a dose of 10 mg/kg per day.Formal Name: 2,2'-[(2-fluoro-1,3-phenylene)bis(methyleneoxy-4,1-phenylene)]bis[N-(1-methylethyl)-1H-benzimidazole-6-carboximidamide, hydrochloride. Molecular Formula: C42H41FN8O2 . XHCl. Formula Weight: 708.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. lambdamax: 223, 264, 316 nm. SMILES: FC1=C(COC2=CC=C(C3=NC4=CC=C(C(NC(C)C)=N)C=C4N3)C=C2)C=CC=C1COC5=CC=C(C6=NC7=CC=C(C(NC(C)C)=N)C=C7N6)C=C5.Cl. InChi Code: InChI=1S/C42H41FN8O2.ClH/c1-24(2)46-39(44)28-12-18-34-36(20-28)50-41(48-34)26-8-14-32(15-9-26)52-22-30-6-5-7-31(38(30)43)23-53-33-16-10-27(11-17-33)42-49-35-19-13-29(21-37(35)51-42)40(45)47-25(3)4,/h5-21,24-25H,22-23H2,1-4H3,(H2,44,46)(H2,45,47)(H,48,50)(H,49,51),1H. InChi Key: GCCVHRQDJGHJEI-UHFFFAOYSA-N.