Dapagliflozin-3-O-beta-D-Glucuronide

Dapagliflozin-3-O-beta-D-glucuronide is a metabolite of dapagliflozin (Cay-11574). Dapagliflozin is a first generation selective sodium glucose cotransporter (SGLT) 2 inhibitor that blocks glucose transport. Dapagliflozin is metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A9 to dapagliflozin-3-O-beta-D-glucuronide, which is 2,600-fold less potent than the parent compound with regard to SGLT2 inhibition.Formal Name: (1S)-1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-3-O-beta-D-glucopyranuronosyl-D-glucitol. CAS Number: 1351438-75-9. Molecular Formula: C27H33ClO12. Formula Weight: 585.0. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: Soluble, Methanol: Soluble, Water: Soluble. SMILES: ClC(C=CC([C@H]1[C@H](O)[C@@H](O[C@@]2([H])[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O2)[C@H](O)[C@@H](CO)O1)=C3)=C3CC4=CC=C(OCC)C=C4. InChi Code: InChI=1S/C27H33ClO12/c1-2-37-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)28)23-22(34)24(18(30)17(11-29)38-23)39-27-21(33)19(31)20(32)25(40-27)26(35)36/h3-8,10,17-25,27,29-34H,2,9,11H2,1H3,(H,35,36)/t17-,18-,19+,20+,21-,22+,23+,24+,25+,27-/m1/s1. InChi Key: ZYZULHSUKTZGTR-PTNNFGGUSA-N.