64 products were found matching "K14382"!

0.5mg/ml if reconstituted with 0.2ml sterile DI water. The sodium/glucose cotransporter 2 (SGLT2) is a protein that in humans is encoded by the SLC5A2 gene. It is mapped to 16p11.2. This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The...

White solid. Soluble in DMSO. Slightly soluble in water or ethanol. Antidiabetic agent, Potent and selective sodium glucose co-transporter 2 (SGLT-2) inhibitor. >,300-fold selectivity over SGLT-1, 4, 5 and 6, SGLT-2 is found almost exclusively in the proximal tubules of nephronic components in kidneys. Inhibition...

Description: Empagliflozin (BI 10773) is an SGLT-2 inhibitor (IC50=3.1 nM) that is potent and selective, with more than 300-fold selectivity for SGLT-1/4/5/6. Empagliflozin is used for the treatment of type 2 diabetes. Target: SGLT. Smiles:...

Dapagliflozin is an inhibitor of sodium-glucose transporter 2 (SGLT2, IC50s = 1.12 and 3 nM for the human and rat enzymes, respectively). It is selective for SGLT2 over SGLT1 (IC50s = 1,391 and 620 nM for the human and rat enzymes, respectively) and human adipocyte glucose transporter (GLUT) activity at 20 µM....

Empagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor (IC50 = 3.1 nM for the human transporter). It is selective for SGLT2 over SGLT1, -4, -5, and -6 (IC50s = 8.3, 11, 1.1, and 2 µM, respectively). Dietary administration of empagliflozin (0.03% for 10 weeks) reduces non-fasting blood glucose levels, as...

Canagliflozin is an inhibitor of sodium-glucose cotransporter 2 (SGLT2, IC50 = 2.2 nM) that less potently blocks SGLT1 (IC50 = 910 nM). Canagliflozin is orally bioavailable and lowers plasma glucose by lowering the renal threshold for glucose and increasing urinary glucose excretion in animals. Formulations...

Sotagliflozin is an inhibitor of sodium-glucose cotransporters (SGLTs, IC50s = 36 and 1.8 nM for human SGLT1 and SGLT2, respectively). It increases plasma glucagon-like peptide 1 (GLP-1) and peptide YY (PYY) levels, as well as glucose levels in the small intestine, cecum, and colon, in mice when administered at a...

5-Methylcytidine is a modified nucleoside derived from 5-methylcytosine and is a minor constituent of RNA as well as DNA for certain organisms. Roughly one to two residues of 5-methylcytidine occur in every 1,000 RNA residues. It has been used in epigenetics research, especially in studies involving DNA methylation...

Dapagliflozin-3-O-beta-D-glucuronide is a metabolite of dapagliflozin (Cay-11574). Dapagliflozin is a first generation selective sodium glucose cotransporter (SGLT) 2 inhibitor that blocks glucose transport. Dapagliflozin is metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A9 to...

Empagliflozin-d4 is intended for use as an internal standard for the quantification of empagliflozin (Cay-17375) by GC- or LC-MS. Empagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor (IC50 = 3.1 nM for the human transporter). It is selective for SGLT2 over SGLT1, -4, -5, and -6 (IC50s = 8.3, 11, 1.1,...

Ipragliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor (IC50 = 7.4 nM in CHO cells expressing the human cotransporter). It is selective for SGLT2 over SGLT1, SGLT3, SGLT4, SGLT5, and SGLT6 (IC50s = 1.9, 30.4, 15.9, 0.46, and 10.4 µM, respectively). Ipragliflozin (0.1-3 mg/kg) decreases plasma levels of...

SGLT2 inhibitor