Daltroban

Daltroban is a thromboxane receptor (TP) antagonist. It inhibits aggregation of isolated human platelets induced by the TP agonist U-46619 (Item no. 16450, IC50 = 77 nM). Daltroban increases mean pulmonary arterial pressure (MPAP), mean arterial pressure (MAP), and hematocrit levels in anesthetized rats (ED50s = 20, 217, and 94 µg/kg, respectively). It maintains post-reinfusion MAP and superior mesenteric artery flow in a cat model of hemorrhagic shock when administered at a dose of 1 mg/kg. Daltroban (0.25-2 mg/kg) increases survival and decreases circulating platelet count in a rabbit model of sodium arachidonate-induced sudden death.Formal Name: 4-[2-[[(4-chlorophenyl)sulfonyl]amino]ethyl]-benzeneacetic acid. CAS Number: 79094-20-5. Synonyms: BM 13505, SKF 96148. Molecular Formula: C16H16ClNO4S. Formula Weight: 353.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 222 nm. SMILES: O=S(NCCC1=CC=C(CC(O)=O)C=C1)(C2=CC=C(Cl)C=C2)=O. InChi Code: InChI=1S/C16H16ClNO4S/c17-14-5-7-15(8-6-14)23(21,22)18-10-9-12-1-3-13(4-2-12)11-16(19)20/h1-8,18H,9-11H2,(H,19,20). InChi Key: IULOBWFWYDMECP-UHFFFAOYSA-N.