Cyclopamine
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Description: Cyclopamine (11-Deoxojervine), a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12... more
Product information "Cyclopamine"
Description: Cyclopamine (11-Deoxojervine), a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids. Target: Endogenous Metabolite, Hedgehog/Smoothened, Smo. Smiles: [H][C@@]12CC3O[C@]4([H])C[C@H](C)CN[C@@]4([H])[C@@H](C)[C@@]3([H])C(C)=C1C[C@@]1([H])[C@@]2([H])CC=C2C[C@@H](O)CC[C@]12C. References: Peukert S, et al. Identification and structure-activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signaling pathway. Bioorg Med Chem Lett. 2009 Jan 15,19(2):328-31.
| Keywords: | 11-Deoxojervine |
| Supplier: | TargetMol |
| Supplier-Nr: | T2825 |
Properties
| Application: | Biochemical studies |
| MW: | 411.62 D |
| Formula: | C27H41NO2 |
Database Information
| CAS : | 4449-51-8| Matching products |
| KEGG ID : | K09381 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H341, H361 |
| P Phrases: | P201, P202, P280, P308+313, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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