Cyclo(RGDfK)

Cyclo(RGDfK) is a synthetic lipopeptide inhibitor of alphavbeta3 integrin (IC50 = 1.33 nM). Osteoblast cultures, which express alphavbeta5 and alphavbeta3 integrins, but not M21L cells that do not express these integrins, bind to cyclo(RGDfK)-coated surfaces. Cyclo(RGDfK) is taken up into tumors in vivo and in vitro and it has been polymerized or conjugated to various fluorophores, radiolabels, and peptide sequences for use in fluorescent and PET imaging to study tumor cell adhesion.Formal Name: cyclo(L-arginylglycyl-L-alpha-aspartyl-D-phenylalanyl-L-lysyl). CAS Number: 161552-03-0. Synonyms: Cyclo(Arg-Gly-Asp-D-Phe-Lys). Molecular Formula: C27H41N9O7. Formula Weight: 603.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 15 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: NC(NCCC[C@@H](C(NCC(N[C@H]1CC(O)=O)=O)=O)NC([C@H](CCCCN)NC([C@@H](CC2=CC=CC=C2)NC1=O)=O)=O)=N. InChi Code: InChI=1S/C27H41N9O7/c28-11-5-4-9-18-24(41)34-17(10-6-12-31-27(29)30)23(40)32-15-21(37)33-20(14-22(38)39)26(43)36-19(25(42)35-18)13-16-7-2-1-3-8-16/h1-3,7-8,17-20H,4-6,9-15,28H2,(H,32,40)(H,33,37)(H,34,41)(H,35,42)(H,36,43)(H,38,39)(H4,29,30,31)/t17-,18-,19+,20-/m0/s1. InChi Key: NVHPXYIRNJFKTE-HAGHYFMRSA-N.