CX-4945 . hydrochloride [Silmitasertib . HCl]

CX-4945 . hydrochloride [Silmitasertib . HCl]
%
Item number Size Datasheet Manual SDS Delivery time Quantity Discount Price
AG-CR1-3629-M001 1 mg -

3 - 9 business days*

10 %
77.00€
69.30€
AG-CR1-3629-M005 5 mg -

3 - 9 business days*

10 %
198.00€
178.20€
 
Yellow solid. Soluble in DMSO. Insoluble in water. Orally active, potent and selective... more
Product information "CX-4945 . hydrochloride [Silmitasertib . HCl]"
Yellow solid. Soluble in DMSO. Insoluble in water. Orally active, potent and selective ATP-competitive inhibitor of the protein kinase CK2 (IC50=1nM), Anticancer compound. Inhibits proliferation in a panel of cancer cell lines that overexpress CK2. Inhibited migration, blocks survival and induces apoptosis in cancer stem cells, glioblastomas and leukemia cells, Shown to decrease the glucose metabolism in cancer cells, Potent inhibitor of Cdc2-like kinases (Clks) in vitro, consequently interfering with alternative splicing, Potent ATP-competitive inhibitor of DYRK1A (IC50=6.8nM), involved in neurodegeneration-associated diseases, CK2alpha deletion selectively increased M3 muscarinic receptors (M3Rs)-mediated insulin secretion from pancreatic islets, Promoted cAMP-induced thermogenesis in white adipocytes, CK2 inhibition ameliorates diet-induced obesity and insulin resistance in mice in vivo by promoting UCP1-dependent thermogenesis.
Keywords: Silmitasertib . HCl, 8-Carboxy-N-(3-chlorophenyl)benzo[c][2,6] naphthyridin-5-aminium chloride
Supplier: AdipoGen Life Sciences
Supplier-Nr: AG-CR1-3629

Properties

Application: Protein kinase CK2 inhibitor
MW: 386,3 D
Formula: C19H12ClN3O2 . HCl
Purity: >98%
Format: Solid

Database Information

CAS : 1009820-21-6| Matching products
KEGG ID : K03097 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "CX-4945 . hydrochloride [Silmitasertib . HCl]"
Write a review
or to review a product.
Viewed