Crotamiton

Crotamiton is an ectoparasiticide and antipruritic agent. It blocks the mouse transient receptor potential vanilloid 4 (TRPV4) channel expressed in HEK293 cells in a calcium-dependent manner (IC50s = 223.5 and 15.5 µM in buffer containing 0 and 2 mM calcium, respectively). It inhibits scratching behavior in mice induced by the TRPV4 agonist GSK1016790A (Cay-17289). Topical application of crotamiton (0.025 g of a 10% ointment) also inhibits scratching behavior in mice induced by histamine, serotonin (Cay-14332), and the proteinase-activated receptor 2 (PAR2) agonist SLIGRL-NH2 (Cay-16723). Formulations containing crotamiton have been used to eradicate scabies and in the treatment of symptomatic pruritic skin.Formal Name: N-ethyl-N-(2-methylphenyl)-2-butenamide. CAS Number: 483-63-6. Synonyms: N-Ethyl-o-Crotonotoluidide. Molecular Formula: C13H17NO. Formula Weight: 203.3. Purity: >95%. Formulation: (Request formulation change), A neat oil. Solubility: DMF: 100 mg/ml, DMSO: 100 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml, Ethanol: 50 mg/ml. lambdamax: 205, 208 nm. SMILES: CC1=C(N(CC)C(/C=C/C)=O)C=CC=C1. InChi Code: InChI=1S/C13H17NO/c1-4-8-13(15)14(5-2)12-10-7-6-9-11(12)3/h4,6-10H,5H2,1-3H3/b8-4+. InChi Key: DNTGGZPQPQTDQF-XBXARRHUSA-N.