CPUY192018

An inhibitor of the Keap1-Nrf2 protein-protein interaction (IC50 = 28.5 nM in a TR-FRET assay), induces Nrf2-mediated transcriptional activity in a reporter assay using HepG2 cells, prevents DSS-induced apoptosis and S-phase cell cycle arrest and reduces DSS-induced increases in ROS levels in NCM460 cells at 10 µM, reduces colon shortening and mucosal tissue injury and inflammation in a mouse model of DSS-induced ulcerative colitis, improves visual function in a rat model of retinal ischemia-reperfusion when subcutaneously or topically administered. SMILES: O=C(O)CN(S(=O)(C1=CC=C(C=C1)OC)=O)C2=C3C=CC=CC3=C(N(S(=O)(C4=CC=C(C=C4)OC)=O)CC(O)=O)C=C2. InChi Code: InChI=1S/C28H26N2O10S2/c1-39-19-7-11-21(12-8-19)41(35,36)29(17-27(31)32)25-15-16-26(24-6-4-3-5-23(24)25)30(18-28(33)34)42(37,38)22-13-9-20(40-2)10-14-22/h3-16H,17-18H2,1-2H3,(H,31,32)(H,33,34). InChi Key: KWSIQJUNYMMCTB-UHFFFAOYSA-N