CPI-1205

Description: CPI-1205 is a highly potent and selective inhibitor of EZH2(IC50 : 0.002 µM, EC50 : 0.032 µM) . Target: Histone Methyltransferase. Smiles: [C@H](C)(N1C=2C(C(C(NCC3=C(OC)C=C(C)NC3=O)=O)=C1C)=CC=CC2)C4CCN(CC(F)(F)F)CC4. References: Vaswani RG, et al. Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas. J Med Chem. 2016 Nov 10,59(21):9928-9941.