CP 94,253 (hydrochloride)

CP 94,253 is an agonist of the serotonin (5-HT) receptor subtype 5-HT1B (Ki = 2 nM in a radioligand binding assay). It is selective for 5-HT1B over 5-HT1A, 5-HT1D, 5-HT1C, and 5-HT2 receptors (Kis = 89, 49, 860, and 1,600 nM, respectively). CP 94,253 (10 and 17 mg/kg) reduces aggressive behavior in a resident-intruder test in mice, as well as decreases alcohol-induced aggression in mice with an ED50 value of 3.8 mg/kg. It decreases the time mice spend immobile in the forced swim test by 43%, indicating antidepressant-like activity, when administered at a dose of 5 mg/kg. CP 94,253 (2.5 mg/kg) also increases drinking in the Vogel punished drinking task, indicating anxiolytic-like activity, in rats.Formal Name: 5-propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-pyrrolo[3,2-b]pyridine, monohydrochloride. CAS Number: 845861-39-4. Molecular Formula: C15H19N3O . HCl. Formula Weight: 293.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble, Ethanol: soluble. lambdamax: 220, 258, 300 nm. SMILES: CCCOC1=CC=C2C(C(C3=CCNCC3)=CN2)=N1.Cl. InChi Code: InChI=1S/C15H19N3O.ClH/c1-2-9-19-14-4-3-13-15(18-14)12(10-17-13)11-5-7-16-8-6-11,/h3-5,10,16-17H,2,6-9H2,1H3,1H. InChi Key: PIIOXKQIZCVXMD-UHFFFAOYSA-N.