CP 547,632

CP 547,632 is an orally bioavailable and potent inhibitor of the receptor tyrosine kinases VEGF receptor 2 (VEGFR2) and basic fibroblast growth factor (bFGF) with IC50 values of 11 and 9 nM, respectively, in an enzyme assay. It is selective for VEGFR2 and bFGF over EGFR, PDGF receptor beta (PDGFRbeta), and related tyrosine kinases. CP 547,632 inhibits VEGFR2 autophosphorylation induced by VEGF in porcine aortic endothelial cells transfected with VEGFR2 (IC50 = 6 nM) and in a xenograft mouse model using NIH3T3/H-Ras cells (EC50 = 590 nM). It decreases angiogenesis induced by VEGF or bFGF and suppresses tumor growth in athymic mice.Formal Name: 3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-[[[[4-(1-pyrrolidinyl)butyl]amino]carbonyl]amino]-4-isothiazolecarboxamide. CAS Number: 252003-65-9. Molecular Formula: C20H24BrF2N5O3S. Formula Weight: 532.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 94 mM. lambdamax: 258 nm. SMILES: NC(C1=C(N([H])C(N(CCCCN2CCCC2)[H])=O)SN=C1OCC3=C(F)C=C(Br)C=C3F)=O. InChi Code: InChI=1S/C20H24BrF2N5O3S/c21-12-9-14(22)13(15(23)10-12)11-31-18-16(17(24)29)19(32-27-18)26-20(30)25-5-1-2-6-28-7-3-4-8-28/h9-10H,1-8,11H2,(H2,24,29)(H2,25,26,30). InChi Key: HXHAJRMTJXHJJZ-UHFFFAOYSA-N.