CP 105,696

CP 105,696 is an antagonist of the leukotriene B4 (LTB4) receptor (IC50 = 8.42 nM for the high-affinity receptor in human neutrophils). It inhibits chemotaxis induced by LTB4 (Cay-20110) in isolated human neutrophils (IC50 = 5 nM) and LTB4-induced calcium mobilization in isolated human monocytes (IC50 = 940 nM). CP 105,696 reduces infiltration of neutrophils and eosinophils induced by arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) in guinea pig skin (ED50 = 0.3 mg/kg, p.o.). It decreases blood glucose levels in the glucose tolerance test and reduces hepatic steatosis in a mouse model of obesity induced by a high-fat diet. CP 105,696 decreases disease severity in a mouse model of experimental allergic encephalomyelitis (EAE, ED50 = 8.6 mg/kg). It increases graft survival in a mouse model of allogeneic heart transplantation when administered at a dose of 50 mg/kg.Formal Name: 1-[(3S,4R)-3-([1,1'-biphenyl]-4-ylmethyl)-3,4-dihydro-4-hydroxy-2H-1-benzopyran-7-yl]-cyclopentanecarboxylic acid. CAS Number: 158081-99-3. Molecular Formula: C28H28O4. Formula Weight: 428.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Soluble, DMSO: Soluble. SMILES: O[C@@H]1[C@@H](CC2=CC=C(C3=CC=CC=C3)C=C2)COC4=C1C=CC(C5(C(O)=O)CCCC5)=C4. InChi Code: InChI=1S/C28H28O4/c29-26-22(16-19-8-10-21(11-9-19)20-6-2-1-3-7-20)18-32-25-17-23(12-13-24(25)26)28(27(30)31)14-4-5-15-28/h1-3,6-13,17,22,26,29H,4-5,14-16,18H2,(H,30,31)/t22-,26+/m0/s1. InChi Key: KMNLXCBYBKHKSK-BKMJKUGQSA-N.