25 products were found matching "K04296"!

The dihydroxy-leukotriene, leukotriene B4 (LTB4) is a member of the G protein-coupled receptor (GPCR) family, in a subfamily of GPCRs that includes receptors for chemokines and other chemotactic factors. Recently, a second, lower affinity receptor for LTB4 (BLT2) has also been cloned, with broader ligand specificity...

CP 105,696 is an antagonist of the leukotriene B4 (LTB4) receptor (IC50 = 8.42 nM for the high-affinity receptor in human neutrophils). It inhibits chemotaxis induced by LTB4 (Cay-20110) in isolated human neutrophils (IC50 = 5 nM) and LTB4-induced calcium mobilization in isolated human monocytes (IC50 = 940 nM). CP...

The leukotriene B4 receptor 1 (BLT1 receptor), cloned from HL-60 human leukemia cells, has 352 amino acids and seven putative membrane-spanning domains. The primary structure of the receptor is identical to that of a putative purinoceptor, P2Y7, which binds to micromolar concentrations of ATP. Northern blotting...

Protein function: Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium...

Protein function: Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium...

The human BLT1 receptor is a G protein-coupled receptor that mediates the proinflammatory effects of leukotriene B4 (LTB4). Northern blotting reveals that the BLT1 receptor is highly expressed in leukocytes, U937 cells, and to a much lower extent in spleen and thymus. Sheep lung membranes have also been identified...

Protein function: Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium...

The leukotriene B4 receptor 1 (BLT1 receptor), cloned from HL-60 human leukemia cells, has 352 amino acids and seven putative membrane-spanning domains. The primary structure of the receptor is identical to that of a putative purinoceptor, P2Y7, which binds to micromolar concentrations of ATP. Northern blotting...

BLT1 is a high-affinity G protein-coupled receptor for leukotriene B4 (LTB4) with roles in the pathogenesis of various inflammatory and immune diseases. It is expressed in most immune cells, including neutrophils, macrophages, eosinophils, and T cells, as well as certain non-immune cells, such as endothelial cells,...

Description: CP-105696 is a potent and selective leukotriene B4 (LTB4) receptor antagonist used to study allograft rejection. Target: LTR. Smiles: O[C@@H]1[C@@H](Cc2ccc(cc2)-c2ccccc2)COc2cc(ccc12)C1(CCCC1)C(O)=O. References: Weringer EJ, et al. Antagonizing leukotriene B4 receptors delays cardiac allograft rejection...