COX-2-IN-6

Description: COX-2-IN-6 is a potent, selective, and orally available cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 0.84 µM and a Ki of 69 nM.COX-2-IN-6 inhibits COX-2-driven PGE2 synthesis with an IC50 of 0.60 µM.COX-2-IN-6 is used to prevent colorectal cancer. COX-2-IN-6 can be used to prevent colorectal cancer. Target: COX, Prostaglandin Receptor. Smiles: O(CC(C)(C)O)C1=C(C=C(CO)C(OCCC)=N1)C2=CC=C(S(C)(=O)=O)C=C2. References: Zhang Z, et al. Gut-Restricted Selective Cyclooxygenase-2 (COX-2) Inhibitors for Chemoprevention of Colorectal Cancer. J Med Chem. 2021 Aug 12,64(15):11570-11596.