A gut-restricted COX-2 inhibitor (IC50 = 0.84 µM), selective for COX-2 over COX-1 (IC50 = >50 µM), inhibits PGE2 production in HEK293 cells expressing COX-2 but those expressing COX-1 (IC50s = 0.6 and >50 µM, respectively), selectively accumulates in the colon versus the plasma at a ratio of 492:1 and reduces total...

Description: COX-2-IN-6 is a potent, selective, and orally available cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 0.84 µM and a Ki of 69 nM.COX-2-IN-6 inhibits COX-2-driven PGE2 synthesis with an IC50 of 0.60 µM.COX-2-IN-6 is used to prevent colorectal cancer. COX-2-IN-6 can be used to prevent colorectal...