Corynantheidine

Corynantheidine is an alkaloid that has been found in M. speciosa (Kratom in Thai) and has antinociceptive activity. It is a partial agonist of the µ-opioid receptor that lacks beta-arrestin recruitment activity. Corynantheidine selectively binds to µ-opioid receptors over kappa- and delta-opioid receptors (Kis = 57.1, 385.4, and 172 nM, respectively, for the mouse receptors) and is selective for the µ-opioid receptor (EC50 = 104.24 nM) over the kappa- and delta-opioid receptors, for which it has no activity, in [35S]GTPgammaS assays. It also binds to alpha1D- and alpha2A-adrenergic receptors and NMDA receptors (Kis = 41, 74, and 83 nM, respectively, for the human receptors), among others. Corynantheidine (10-100 nmol, i.c.v.) increases the latency to tail withdrawal in the tail-flick test in mice.Formal Name: (alphaE,2S,3S,12bS)-3-ethyl-1,2,3,4,6,7,12,12b-octahydro-alpha-(methoxymethylene)-indolo[2,3-a]quinolizine-2-acetic acid, methyl ester. CAS Number: 23407-35-4. Synonyms: (-)-Corynantheidine, 9-demethoxy Mitragynine. Molecular Formula: C22H28N2O3. Formula Weight: 368.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 2 mg/ml. lambdamax: 227 nm. SMILES: CC[C@@H]1CN2[C@@](C(NC3=CC=CC=C34)=C4CC2)([H])C[C@@H]1/C(C(OC)=O)=C\OC. InChi Code: InChI=1S/C22H28N2O3/c1-4-14-12-24-10-9-16-15-7-5-6-8-19(15)23-21(16)20(24)11-17(14)18(13-26-2)22(25)27-3/h5-8,13-14,17,20,23H,4,9-12H2,1-3H3/b18-13+/t14-,17+,20+/m1/s1. InChi Key: NMLUOJBSAYAYEM-QALMDFCDSA-N.