Corydaline

Corydaline is an alkaloid that has been found in C. cava and has diverse biological activities. It inhibits acetylcholinesterase (AChE, IC50 = 15 µM). Corydaline is nematocidal against S. ratti and S. venezuelensis third instar larvae with 50% paralysis (PC50) values of 18 and 30 µM, respectively. It inhibits thrombin-induced platelet aggregation in vitro (IC50 = 54.16 µg/ml). Corydaline (1 and 3 mg/kg) increases gastric emptying in rat models of apomorphine- and laparotomy-induced delayed gastric emptying.Formal Name: 5,8,13S,13aR-tetrahydro-2,3,9,10-tetramethoxy-13-methyl-6H-dibenzo[a,g]quinolizine. CAS Number: 518-69-4. Synonyms: (+)-Corydaline, D-Corydaline, NSC 406036. Molecular Formula: C22H27NO4. Formula Weight: 369.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 5mg/mL, DMSO: 5mg/mL, DMSO:PBS (pH 7.2) (1:5): 0.16mg/mL. SMILES: COC1=CC=C2C(CN(CCC3=CC(OC)=C(OC)C=C34)[C@]4([H])[C@H]2C)=C1OC. InChi Code: InChI=1S/C22H27NO4/c1-13-15-6-7-18(24-2)22(27-5)17(15)12-23-9-8-14-10-19(25-3)20(26-4)11-16(14)21(13)23/h6-7,10-11,13,21H,8-9,12H2,1-5H3/t13-,21+/m0/s1. InChi Key: VRSRXLJTYQVOHC-YEJXKQKISA-N. Origin: Plant/Corydalis yanhusuo.