Cortexolone 17alpha-propionate

Cortexolone 17alpha-propionate is a peripherally selective androgen receptor antagonist. Cortexolone 17alpha-propionate binds to the androgen receptor (AR) and inhibits AR-regulated transcription in a reporter assay. It also inhibits androgen-regulated lipid synthesis in primary human sebocytes. Cortexolone 17alpha-propionate inhibits inflammatory cytokine production from primary human sebocytes and scalp dermal papilla cells. It inhibits testosterone propionate-induced flank organ enlargement in Syrian golden hamsters by 84% when administered topically at a dose of 400 µg/animal.Formal Name: 21-hydroxy-17-(1-oxopropoxy)-pregn-4-ene-3,20-dione. CAS Number: 19608-29-8. Synonyms: CB-03-01. Molecular Formula: C24H34O5. Formula Weight: 402.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 20mg/mL, DMSO: 10mg/mL, Ethanol: 20mg/mL, Ethanol:PBS (pH 7.2) (1:9): 0.1mg/mL. lambdamax: 240, 295 nm. SMILES: O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4(OC(CC)=O)C(CO)=O)=C1. InChi Code: InChI=1S/C24H34O5/c1-4-21(28)29-24(20(27)14-25)12-9-19-17-6-5-15-13-16(26)7-10-22(15,2)18(17)8-11-23(19,24)3/h13,17-19,25H,4-12,14H2,1-3H3/t17-,18+,19+,22+,23+,24+/m1/s1. InChi Key: GPNHMOZDMYNCPO-PDUMRIMRSA-N.