Cornuside

Cornuside is a bisiridoid glycoside that has been found in C. officinalis and has diverse biological activities. It induces osteogenic differentiation of isolated human bone mesenchymal stem cells (BMSCs) when used at concentrations of 10, 30, and 60 µM. In vivo, cornuside (150 mg/kg) reduces demyelination, focal inflammation, and T helper 17 (Th17) cell spinal cord infiltration, as well as improves neurological deficits in a rat model of experimental autoimmune encephalomyelitis (EAE). Cornuside (0.4 and 0.8 mg/kg) decreases mortality, vascular instability, and pulmonary leukocyte infiltration in a mouse model of cecal ligation and puncture-induced sepsis. It also reduces polydipsia and polyphagia, lowers fasting blood glucose levels, prevents testicular cell apoptosis, and decreases the abundance of Weissella, Clostridium, Anaerotruncus, and Bilophila in the gut microbiome in KK/Ay diabetic mice.Formal Name: 3-ethenyl-2-(beta-D-glucopyranosyloxy)-3,4-dihydro-4-[2-[(3,4,5-trihydroxybenzoyl)oxy]ethyl]-2H-pyran-5-carboxylic acid, methyl ester. CAS Number: 131189-57-6. Synonyms: Cornuside I. Molecular Formula: C24H30O14. Formula Weight: 542.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 220 nm. SMILES: O=C(C1=COC(C(C1CCOC(C2=CC(O)=C(C(O)=C2)O)=O)C=C)OC3OC(C(C(C3O)O)O)CO)OC. InChi Code: InChI=1S/C24H30O14/c1-3-11-12(4-5-35-21(32)10-6-14(26)17(28)15(27)7-10)13(22(33)34-2)9-36-23(11)38-24-20(31)19(30)18(29)16(8-25)37-24/h3,6-7,9,11-12,16,18-20,23-31H,1,4-5,8H2,2H3. InChi Key: SMTKSCGLXONVGL-UHFFFAOYSA-N. Origin: Plant/Cornus officinalis.