Description: 1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardial I/R and protect the liver from CCl4-induced acute hepatotoxicity, by reducing...

Cornuside is a bisiridoid glycoside that has been found in C. officinalis and has diverse biological activities. It induces osteogenic differentiation of isolated human bone mesenchymal stem cells (BMSCs) when used at concentrations of 10, 30, and 60 µM. In vivo, cornuside (150 mg/kg) reduces demyelination, focal...