Conessine

Conessine is a steroidal alkaloid that has been found in H. antidysenterica and has diverse biological activities. It is active against a variety of Gram-positive and Gram-negative bacteria, including B. subtilis, S. aureus, M. luteus, and E. coli (MICs = 15.6-1,000 µg/disc in agar diffusion assays), the amoeba E. histolytica, as well as P. falciparum schizonts (IC50 = 1.9 µg/ml). Conessine inhibits replication of the coronaviruses HCoV-OC43, HCoV-NL63, MERS-CoV, and MHV-A59 in infected cells with EC50 values of 2.34, 10.75, 4.98, and 11.46 µM, respectively. It is also a histamine H3 receptor antagonist (Kis = 5.37 and 12.3 nM for the human and rat receptors, respectively). Conessine (10 mg/kg) reduces parasitemia in a mouse model of P. berghei infection.Formal Name: N,N-dimethyl-con-5-enin-3beta-amine. CAS Number: 546-06-5. Synonyms: Neriine, NSC 119994, Roquessine, Wrightine. Molecular Formula: C24H40N2. Formula Weight: 356.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, Ethanol: 16 mg/ml, Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml. SMILES: C[C@H]1[C@@]2([H])CC[C@@]3([H])[C@]4([H])CC=C5C[C@@H](N(C)C)CC[C@]5(C)[C@@]4([H])CC[C@@]32CN1C. InChi Code: InChI=1S/C24H40N2/c1-16-20-8-9-22-19-7-6-17-14-18(25(3)4)10-12-23(17,2)21(19)11-13-24(20,22)15-26(16)5/h6,16,18-22H,7-15H2,1-5H3/t16-,18-,19+,20+,21-,22-,23-,24-/m0/s1. InChi Key: GPLGAQQQNWMVMM-MYAJQUOBSA-N. Origin: Plant/Holarrhena antidyssentrica.