Colcemid

Semisynthetic from colchicine (Prod. No. AG-CN2-0048). Anti-cancer compound - Cell synchronization agent - Used as a drug in chemotherapy by synchronizing tumor cells at metaphase, the radiosensitive stage of the cell cycle - Microtubule assembly inhibitor - Depolymerizes microtubules and limits microtubule formation (inactivates spindle fibre formation) - Inhibits mitosis during cell division at metaphase by inhibiting spindle formation - Low concentrations affect microtubule dynamics and cell migration, while high concentrations promote microtubule detachment from microtubule organizing center - Apoptosis inducer - Thrombopoietic agent.