CNX-774

CNX-774 is a potent, selective, and irreversible inhibitor of Bruton's tyrosine kinase (BTK), an important kinase in the B cell antigen receptor pathway, with IC50 values of 50 = 2.82 and 0.38 µM) but has no effect on cell cycle progression.Formal Name: 4-[4-[[5-fluoro-4-[[3-[(1-oxo-2-propen-1-yl)amino]phenyl]amino]-2-pyrimidinyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide. CAS Number: 1202759-32-7. Molecular Formula: C26H22FN7O3. Formula Weight: 499.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS(pH 7.2)(1:6): 0.14 mg/ml, DMSO: 25 mg/ml. lambdamax: 272 nm. SMILES: [H]N(C(C=C)=O)C1=CC(N([H])C2=NC(N(C3=CC=C(OC4=CC(C(N(C)[H])=O)=NC=C4)C=C3)[H])=NC=C2F)=CC=C1. InChi Code: InChI=1S/C26H22FN7O3/c1-3-23(35)31-17-5-4-6-18(13-17)32-24-21(27)15-30-26(34-24)33-16-7-9-19(10-8-16)37-20-11-12-29-22(14-20)25(36)28-2/h3-15H,1H2,2H3,(H,28,36)(H,31,35)(H2,30,32,33,34). InChi Key: VVLHQJDAUIPZFH-UHFFFAOYSA-N.