CM-4620
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An inhibitor of Orai1/STIM1-containing SOCs (IC50 = 120 nM), selective for Orai1/STIM1-containing... more
Product information "CM-4620"
An inhibitor of Orai1/STIM1-containing SOCs (IC50 = 120 nM), selective for Orai1/STIM1-containing SOCs over Orai2/STIM2-containing SOCs (IC50 = 900 nM), decreases cholecystokinin- or taurolithocholic acid 3-sulfate-induced cell death in isolated mouse, rat, and human acini at 3 µM, reduces blood amylase and lipase levels and pancreatic trypsin activity in a mouse model of cerulein-induced acute pancreatitis at 20 mg/kg. Formulation: A solid. InChI: InChI=1S/C19H11ClF3N3O3/c1-9-3-2-4-12(21)17(9)18(27)26-16-8-24-13(7-25-16)10-5-14-15(6-11(10)20)29-19(22,23)28-14/h2-8H,1H3,(H,25,26,27). InChIKey: QQMKTHUGOQDEIL-UHFFFAOYSA-N. SMILES: O=C(C1=C(C)C=CC=C1F)NC2=CN=C(C3=CC4=C(C=C3Cl)OC(F)(F)O4)C=N2
| Keywords: | Zegrocractin, N-[5-(6-chloro-2,2-difluoro-1,3-benzodioxol-5-yl)-2-pyrazinyl]-2-fluoro-6-methyl-benzamide |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 41977 |
Properties
| Application: | Orai1/STIM1-containing SOC (store-operated calcium channel) inhibitor |
| Immunogen: | 421.8 |
| MW: | 421.8 D |
| Formula: | C19H11ClF3N3O3 |
| Purity: | >98% |
| Format: | Solid |
Database Information
| CAS : | 1713240-67-5| Matching products |
| KEGG ID : | K16059 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: -20°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302 |
| P Phrases: | P264, P270, P301+310, P330, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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