CLP257
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: CLP257 is a selective K+-Cl- cotransporter KCC2 activator (EC50: 616 nM) and it is... more
Product information "CLP257"
Description: CLP257 is a selective K+-Cl- cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 alleviates hypersensitivity in rats with neuropathic painc and it also modulates plasmalemmal KCC2 protein turnover post-translationally. CLP257 restores impaired Cl- transport in neurons with diminished KCC2 activity. Target: Potassium Channel. Smiles: Oc1cc(F)ccc1\C=C1/SC(=NC1=O)N1CCCCN1. References: Gagnon M, et al. Chloride extrusion enhancers as novel therapeutics for neurological diseases. Nat Med. 2013 Nov,19(11):1524-8.
| Supplier: | TargetMol |
| Supplier-Nr: | T14984 |
Properties
| Application: | KCC2 cotransporter activator |
| MW: | 307.34 D |
| Formula: | C14H14FN3O2S |
Database Information
| CAS : | 1181081-71-9| Matching products |
| KEGG ID : | K23967 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302 |
| P Phrases: | P264, P270, P330, P301+P310, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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