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Item number: Cay30948-5

CLP 257 is a K+/Cl- cotransporter 2 (KCC2) activator. It induces chloride transport in NG108-cl cells that endogenously express low levels of KCC2 (EC50 = 616 nM). It is selective for KCC2 over GABAA receptors at 50 µM. CLP 257 (25 µM) increases the rate of chloride accumulation in spinal slices isolated from a rat...

Keywords:	(5Z)-5-[(4-fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1(2H)-pyridazinyl)-4(5H)-thiazolone
Application:	KCC2 cotransporter activator
CAS	1181081-71-9
MW:	307.3 D

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CLP257

Item number: TGM-T14984-100mg

Description: CLP257 is a selective K+-Cl- cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 alleviates hypersensitivity in rats with neuropathic painc and it also modulates plasmalemmal KCC2 protein turnover post-translationally. CLP257 restores...

Application:	KCC2 cotransporter activator
CAS	1181081-71-9
MW:	307.34 D

From 37.00€ *

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