Clotrimazole

Clotrimazole is an imidazole antifungal that is active against a wide variety of fungal forms and is effective in many types of fungal infections. It tightly binds sterol 14-alpha demethylase isoform B from A. fumigatus (KD = 103 nM) and, like other imidazoles, disturbs the fungal cell membrane. In mammalian cells, clotrimazole potently inhibits the calcium-dependent potassium channels Kv1.3 and IK-1 (IC50 = 6.0 and 0.07 µM, respectively).Formal Name: 1-[(2-chlorophenyl)diphenylmethyl]-1H-imidazole. CAS Number: 23593-75-1. Synonyms: BAY-B-5087, NSC 257473. Molecular Formula: C22H17ClN2. Formula Weight: 344.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml, DMSO: 3 mg/ml, Ethanol: 10 mg/ml. SMILES: ClC1=CC=CC=C1C(C2=CC=CC=C2)(C3=CC=CC=C3)N4C=CN=C4. InChi Code: InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H. InChi Key: VNFPBHJOKIVQEB-UHFFFAOYSA-N.