CITCO

CITCO is an agonist of human CAR (EC50 = 49 nM). It induces nuclear translocation of human CAR in hepatocytes, followed by increased expression of CAR-regulated genes, including several cytochrome P450 isoforms. CITCO less potently activates human pregnane X receptor (EC50 = 3 µM) and has no detectable activity on other nuclear receptors at 10 µM. It is selective for human CAR, whereas TCPOBOP (Cay-14140) is selective for mouse CAR. CITCO does activate alternative splice variants of human CAR that are also found in liver cells. It is commonly used to study the action of human CAR in hepatocytes.Formal Name: O-[(3,4-dichlorophenyl)methyl]oxime 6-(4-chlorophenyl)-imidazo[2,1-b]thiazole-5-carboxaldehyde. CAS Number: 338404-52-7. Molecular Formula: C19H12Cl3N3OS. Formula Weight: 436.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 10 mg/ml. lambdamax: 203, 260, 315 nm. SMILES: ClC1=CC=C(C2=C(/C=N/OCC3=CC(Cl)=C(Cl)C=C3)N4C(SC=C4)=N2)C=C1. InChi Code: InChI=1S/C19H12Cl3N3OS/c20-14-4-2-13(3-5-14)18-17(25-7-8-27-19(25)24-18)10-23-26-11-12-1-6-15(21)16(22)9-12/h1-10H,11H2/b23-10+. InChi Key: ZQWBOKJVVYNKTL-AUEPDCJTSA-N.