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Product information "cis-Flupenthixol (hydrochloride)"
cis-Flupenthixol is a typical antipsychotic, a dopamine D2 receptor antagonist (Ki = 0.38 nM), and an inverse agonist at the serotonin (5-HT) receptor subtype 5-HT2A (Ki = 7 nM). In vivo, cis-flupenthixol (0.5 mg/kg, i.p.) reduces cocaine-induced locomotor activity and prevents development of conditioned place preferences for the immediate effects of intravenously administered cocaine without affecting development of conditioned place aversions in rats. cis-Flupenthixol also inhibits acid sphingomyelinase activity by 81.8% when used at a concentration of 10 mM.Formal Name: 4-[3-[(3Z)-2-(trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-1-piperazineethanol, dihydrochloride. CAS Number: 51529-01-2. Synonyms: cis-Flupentixol. Molecular Formula: C23H25F3N2OS . 2HCl. Formula Weight: 507.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMSO: 25 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 230 nm. SMILES: OCCN(CC1)CCN1CC/C=C2C3=C(C=CC(C(F)(F)F)=C3)SC4=CC=CC=C4\2.Cl.Cl. InChi Code: InChI=1S/C23H25F3N2OS.2ClH/c24-23(25,26)17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)30-22)5-3-9-27-10-12-28(13-11-27)14-15-29,,/h1-2,4-8,16,29H,3,9-15H2,2*1H/b18-5-,,. InChi Key: IOVDQEIIMOZNNA-MHKBYHAFSA-N.
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