Ciliobrevin A

Ciliobrevin A is a hedgehog pathway inhibitor that blocks sonic hedgehog (Shh)-induced hedgehog pathway activation (IC50 = 7 µM). It disrupts primary cilia formation and inhibits the dynein-dependent microtubial gliding and ATPase activities of the cytoplasmic ATPases associated with various cellular activities (AAA+) family. Ciliobrevin A also inhibits mammalian target of rapamycin complex 1 (mTORC1) activity in uninfected and human cytomegalovirus (HCMV)-infected cells, suggesting that mTORC1 activation requires dynein-dependent transport for cellular activation.Formal Name: 2,4-dichloro-alpha-(3,4-dihydro-4-oxo-2(1H)-quinazolinylidene)-beta-oxo-benzenepropanenitrile. CAS Number: 302803-72-1. Synonyms: HPI-4. Molecular Formula: C17H9Cl2N3O2. Formula Weight: 358.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 331 nm. SMILES: O=C(N/1)C2=CC=CC=C2NC1=C(C#N)\C(C3=C(Cl)C=C(Cl)C=C3)=O. InChi Code: InChI=1S/C17H9Cl2N3O2/c18-9-5-6-10(13(19)7-9)15(23)12(8-20)16-21-14-4-2-1-3-11(14)17(24)22-16/h1-7,21H,(H,22,24)/b16-12-. InChi Key: SESYPWCSIZUIAS-VBKFSLOCSA-N.