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Ciliobrevin A
Item number: TGM-T3156-100mg
Description: Ciliobrevin A (HPI-4) is an inhibitor of the hedgehog signaling pathway with an IC50 of less than 10 µM. Target: Hedgehog/Smoothened. Smiles: Clc1ccc(C(=O)C(\C#N)=C2\NC(=O)c3ccccc3N2)c(Cl)c1. References: Hyman JM, et al. Proc Natl Acad Sci U S A. 2009, 106(33):14132-7.
| Keywords: | Hedgehog Pathway Inhibitor 4, HPI-4 |
| CAS | 302803-72-1 |
| MW: | 358.18 D |
From 37.00€
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Ciliobrevin A
Item number: Cay22587-5
Ciliobrevin A is a hedgehog pathway inhibitor that blocks sonic hedgehog (Shh)-induced hedgehog pathway activation (IC50 = 7 µM). It disrupts primary cilia formation and inhibits the dynein-dependent microtubial gliding and ATPase activities of the cytoplasmic ATPases associated with various cellular activities...
| Keywords: | HPI-4, 2,4-dichloro-alpha-(3,4-dihydro-4-oxo-2(1H)-quinazolinylidene)-beta-oxo-benzenepropanenitrile |
| Application: | Hedgehog pathway inhibitor |
| CAS | 302803-72-1 |
| MW: | 358.2 D |
From 94.00€
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