CGP 71683 (hydrochloride)

CGP 71683 is an antagonist of neuropeptide Y (NPY) receptor Y5 (IC50 = 1.4 nM in a radioligand binding assay). It is selective for Y5 over Y1, Y2, and Y4 receptors (IC50s = 2,765, 7,187, and 5,637 nM, respectively). It inhibits NPY-induced increases in BT-549 cell growth and MDA-MB-231 cell migration when used at a concentration of 0.25 µM. CGP 71683 (10 mg/kg, i.p.) inhibits increases in food intake induced by intracerebroventricular administration of NPY in rats.Formal Name: N-[[trans-4-[[(4-amino-2-quinazolinyl)amino]methyl]cyclohexyl]methyl]-1-naphthalenesulfonamide, monohydrochloride. CAS Number: 192322-50-2. Synonyms: CGP 71683A. Molecular Formula: C26H29N5O2S . HCl. Formula Weight: 512.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml, Ethanol: 20 mg/ml. lambdamax: 272 nm. SMILES: NC1=NC(NC[C@@H]2CC[C@@H](CNS(C3=CC=CC4=C3C=CC=C4)(=O)=O)CC2)=NC5=C1C=CC=C5.Cl. InChi Code: InChI=1S/C26H29N5O2S.ClH/c27-25-22-9-3-4-10-23(22)30-26(31-25)28-16-18-12-14-19(15-13-18)17-29-34(32,33)24-11-5-7-20-6-1-2-8-21(20)24,/h1-11,18-19,29H,12-17H2,(H3,27,28,30,31),1H/t18-,19-,. InChi Key: DIQDKUNCSVFGHH-VPLSKCCHSA-N.